RESEARCH: SIGNALING PROTEIN
FOLDING PROJECT #18907 PROFILE

The project relates to how small changes in signaling proteins can cause big problems with how cells communicate. These changes can lead to diseases, and many drugs target these proteins.

Note: This TLDR is a simplication and may not be 100% accurate.

Impact of mutations on signaling proteins Mutations in proteins are often found to have dramatic functional consequences through changes in conformational dynamics, ligand binding, and association with signaling partners.

These changes sometimes lead to pathological outcomes.

Additionally, proteins involved in cell signaling are the target of over half of approved drugs.

This project aims to understand how a small number of mutations in signaling proteins can cause a dramatic change in how they modulate cell signaling pathways.

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mutations

Alterations in the DNA sequence of a gene.

Mutations are changes in the genetic code that can affect how proteins function. They can be caused by environmental factors, errors during DNA replication, or inherited from parents. Mutations can have a wide range of effects, from being harmless to causing serious diseases.

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signaling proteins

Proteins that transmit signals within cells and between cells.

Signaling proteins are crucial for communication within and between cells. They relay information about various stimuli, such as growth factors, hormones, and nutrients, triggering specific cellular responses.

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conformational dynamics

The changes in shape of a protein over time.

Conformational dynamics refer to the flexibility and movement of proteins. This constant shifting allows proteins to interact with other molecules and carry out their functions effectively.

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ligand binding

The process of a molecule attaching to a protein.

Ligand binding is essential for many cellular processes. It allows molecules, such as hormones or neurotransmitters, to interact with specific proteins and trigger a response.

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pathological outcomes

Abnormal conditions that result in disease or dysfunction.

Pathological outcomes are the undesirable consequences of disease or injury. They can range from mild symptoms to life-threatening complications.

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cell signaling pathways

Series of molecular interactions that transmit signals within a cell.

Cell signaling pathways are intricate networks of molecules that allow cells to communicate with each other and respond to their environment. They play crucial roles in growth, development, and disease.

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drugs

Substances that are used to treat, prevent, or diagnose disease.

Drugs are chemical compounds designed to interact with specific targets in the body to produce a therapeutic effect. They can be administered orally, intravenously, or through other routes.