RESEARCH: SIGNALING PROTEIN
FOLDING PROJECT #18905 PROFILE

The project relates to how small changes in proteins that control cell signals can cause big problems in how our cells work. These proteins are important because many medicines target them.

Note: This TLDR is a simplication and may not be 100% accurate.

Impact of mutations on signaling proteins Mutations in proteins are often found to have dramatic functional consequences through changes in conformational dynamics, ligand binding, and association with signaling partners.

These changes sometimes lead to pathological outcomes.

Additionally, proteins involved in cell signaling are the target of over half of approved drugs.

This project aims to understand how a small number of mutations in signaling proteins can cause a dramatic change in how they modulate cell signaling pathways.

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Mutations

Permanent alterations in the DNA sequence.

Mutations are changes in the DNA sequence that make up genes. These changes can be caused by errors during DNA replication or exposure to mutagens like radiation. Mutations can have a wide range of effects, from being harmless to causing disease.

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Signaling Proteins

Proteins that transmit signals within cells and between cells.

Signaling proteins are essential for cell communication. They relay messages from the outside of a cell to the inside, triggering specific responses. These responses can include changes in gene expression, cell growth, or movement.

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Conformational Dynamics

The changes in shape that a protein undergoes.

Conformational dynamics refer to the flexibility and movement of proteins. Proteins can change shape depending on their environment and interactions with other molecules. These shape changes are crucial for their function.

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Ligand Binding

The attachment of a molecule to a protein.

Ligand binding is the process where a molecule called a ligand binds to a specific site on a protein. This interaction can activate or inhibit the protein's function.

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Pathological Outcomes

Disease states or abnormal conditions.

Pathological outcomes refer to the development of diseases or abnormal conditions. These can result from various factors, including genetic mutations, environmental exposures, and infections.

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Cell Signaling Pathways

Series of molecular events that transmit signals within cells.

Cell signaling pathways are intricate networks of molecules that allow cells to communicate with each other and respond to their environment. These pathways involve a cascade of interactions, transmitting signals from the cell surface to the nucleus, ultimately regulating gene expression and cellular functions.

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Drugs

Substances that alter biological processes.

Drugs are chemical compounds designed to have a specific effect on the body. They can treat diseases, prevent infections, manage pain, and modify various physiological functions.