RESEARCH: SIGNALING PROTEIN
FOLDING PROJECT #18908 PROFILE

This project explores how small changes (mutations) in proteins that send signals within our cells can drastically change how these signals work. These signaling proteins are crucial for many body functions and are often the target of medicines.

Impact of mutations on signaling proteins Mutations in proteins are often found to have dramatic functional consequences through changes in conformational dynamics, ligand binding, and association with signaling partners.

These changes sometimes lead to pathological outcomes.

Additionally, proteins involved in cell signaling are the target of over half of approved drugs.

This project aims to understand how a small number of mutations in signaling proteins can cause a dramatic change in how they modulate cell signaling pathways.

mutations

Permanent alterations in the DNA sequence.

Mutations are changes in the DNA sequence that can alter gene function. They can be caused by various factors like errors during DNA replication or exposure to mutagens. Mutations can have diverse effects, ranging from harmless to detrimental, influencing protein structure and function.

signaling proteins

Proteins that transmit signals within cells and between cells.

Signaling proteins are essential for communication within and between cells. They receive signals, relay them through a cascade of interactions, and ultimately trigger specific cellular responses like growth, differentiation, or apoptosis. Disruptions in signaling pathways can contribute to various diseases.

conformational dynamics

Changes in the shape and structure of proteins.

Conformational dynamics refer to the constant movement and flexibility of protein structures. These changes are crucial for protein function, allowing them to interact with other molecules and carry out their roles. Alterations in conformational dynamics can affect protein stability and activity.

ligand binding

The interaction between a molecule (ligand) and a protein binding site.

Ligand binding is the process where a molecule, such as a drug or hormone, attaches to a specific site on a protein. This interaction can trigger changes in the protein's structure and function. Understanding ligand binding is essential for developing drugs and designing therapeutic interventions.

signaling pathways

Series of molecular events that transmit signals within cells.

Signaling pathways are complex networks of interconnected molecules that relay information from the cell surface to the nucleus, ultimately regulating gene expression and cellular responses. Dysregulation of signaling pathways can contribute to various diseases.

pathological outcomes

Abnormal or unhealthy conditions resulting from disease processes.

Pathological outcomes refer to the undesirable consequences of disease. They can involve cellular damage, tissue dysfunction, organ failure, and ultimately, death. Understanding pathological outcomes is crucial for developing effective treatments and improving patient care.