RESEARCH: SIGNALING PROTEIN
FOLDING PROJECT #18906 PROFILE

The project relates to how small changes in proteins that send signals within cells can cause big problems with how our bodies work. These changes can lead to diseases and are often targeted by medicines.

Note: This TLDR is a simplication and may not be 100% accurate.

Impact of mutations on signaling proteins Mutations in proteins are often found to have dramatic functional consequences through changes in conformational dynamics, ligand binding, and association with signaling partners.

These changes sometimes lead to pathological outcomes.

Additionally, proteins involved in cell signaling are the target of over half of approved drugs.

This project aims to understand how a small number of mutations in signaling proteins can cause a dramatic change in how they modulate cell signaling pathways.

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mutations

Permanent alterations in the DNA sequence.

Mutations are changes in the genetic code that can affect how genes work. They can be caused by environmental factors or errors during DNA replication. Mutations can have a wide range of effects, from being harmless to causing disease.

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signaling proteins

Proteins that transmit signals within cells or between cells.

Signaling proteins are essential for communication within and between cells. They relay messages from one part of a cell to another or from one cell to another, triggering various cellular responses such as growth, differentiation, and movement.

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conformational dynamics

Changes in the shape of a protein.

Conformational dynamics refers to the various shapes a protein can adopt. These shape changes are crucial for protein function, allowing them to interact with other molecules and carry out their roles.

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ligand binding

The interaction between a protein and a small molecule.

Ligand binding is the process where a small molecule (ligand) attaches to a protein. This interaction often triggers a change in the protein's shape or activity, leading to various cellular responses.

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signaling partners

Other proteins that interact with signaling proteins.

Signaling partners are proteins that work together with signaling proteins to transmit signals within cells. They can amplify or modify the signal, ensuring accurate and coordinated cellular responses.

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pathological outcomes

Harmful or abnormal changes in the body.

Pathological outcomes are the negative consequences that can result from disease or other medical conditions. They can range from mild symptoms to life-threatening complications.

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drugs

Substances that are used to treat or prevent disease.

Drugs are chemical substances designed to have a specific effect on the body. They can be used to treat various conditions, from infections to chronic diseases.