RESEARCH: CANCER
FOLDING PROJECT #17738 PROFILE

This project explores how proteins use ion gradients to move molecules across cell membranes. These 'secondary active transporters' are found everywhere and play a role in treating diseases like cancer and diabetes. By studying them, we can learn how different proteins work together.

Projects 17711-17724 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat disease like cancer, diabetes, and neurological disorders.

These simulations will allow us to understand a universal role of ion-coupling across different families of proteins.

secondary active transporter

Proteins that use ions to transport molecules across cell membranes.

Secondary active transporters are a type of protein found in all living organisms. They play a crucial role in moving various molecules across cell membranes by utilizing an existing ion gradient. This process is essential for many cellular functions, including nutrient uptake, waste removal, and signal transduction. These transporters are also important drug targets for treating diseases like cancer, diabetes, and neurological disorders.

ion gradient

A difference in ion concentration across a cell membrane.

An ion gradient refers to the unequal distribution of charged particles (ions) across a cell membrane. This difference in concentration creates an electrochemical potential that can be used by cells to power various processes, such as nerve impulse transmission and nutrient uptake.

cell membrane

The outer boundary of a cell that separates its internal environment from the outside.

The cell membrane is a thin, flexible barrier that surrounds every cell. It plays a crucial role in regulating what enters and exits the cell, maintaining its shape, and communicating with other cells.

proteins

Large, complex molecules that perform a wide variety of functions in living organisms.

Proteins are the workhorses of cells, carrying out essential tasks such as building and repairing tissues, transporting molecules, catalyzing chemical reactions, and defending against disease.