RESEARCH: CANCER
FOLDING PROJECT #17741 PROFILE

This project studies how proteins use ion gradients to move molecules across cell membranes. These proteins are important for many bodily functions and are often drug targets for diseases like cancer and diabetes. By simulating these proteins, we can learn how they work and develop better treatments.

Projects 17711-17724 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat disease like cancer, diabetes, and neurological disorders.

These simulations will allow us to understand a universal role of ion-coupling across different families of proteins.

Secondary active transporters

Proteins that use ion gradients to transport molecules across cell membranes.

Secondary active transporters are essential proteins found in all living organisms. They work by using the energy from an existing ion gradient to move other molecules across cell membranes. This process is crucial for various cellular functions, including nutrient uptake, waste removal, and signal transduction. Many secondary active transporters are targeted by drugs to treat diseases like cancer, diabetes, and neurological disorders.

Ion

An atom or molecule with a net electrical charge.

Ions are atoms or molecules that have gained or lost electrons, giving them a net positive or negative charge. They play crucial roles in biological systems, such as nerve impulse transmission, muscle contraction, and maintaining fluid balance.

Membrane

A thin barrier that separates the inside of a cell from its external environment.

Membranes are essential structures in cells, separating internal compartments and controlling the passage of molecules in and out. They consist primarily of lipids and proteins, with various functions such as transport, signaling, and providing structural support.

Proteins

Large biomolecules essential for various cellular functions.

Proteins are complex molecules made up of amino acids, performing diverse roles in living organisms. They act as enzymes, structural components, hormones, antibodies, and transporters, among others.

Simulations

Computer models used to mimic real-world processes.

Simulations are powerful tools used in various fields, including biology and medicine. They involve creating computer models that represent real-world systems, allowing researchers to study complex phenomena and predict outcomes.