RESEARCH: CANCER
FOLDING PROJECT #17727 PROFILE

This project looks at how proteins use ions to move molecules across cell membranes. These proteins are found everywhere and help us understand how things like drugs work in the body. The simulations will show how these proteins function across different types of cells.

Projects 17711-17724 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat disease like cancer, diabetes, and neurological disorders.

These simulations will allow us to understand a universal role of ion-coupling across different families of proteins.

secondary active transporters

Proteins that use ions to move molecules across cell membranes.

Secondary active transporters are essential proteins found in all living organisms. They utilize the energy stored in an ion gradient to move other molecules across cell membranes. This process is crucial for various cellular functions, including nutrient uptake, waste removal, and signal transduction. Many secondary active transporters are targets for drugs used to treat diseases like cancer, diabetes, and neurological disorders.

ion gradient

A difference in ion concentration across a cell membrane.

An ion gradient is the unequal distribution of charged particles (ions) across a cell membrane. This difference in concentration creates an electrochemical potential that drives the movement of ions across the membrane. Ion gradients are essential for many cellular processes, including nerve impulse transmission, muscle contraction, and nutrient uptake.

drug targets

Molecules or biological processes that are targeted by drugs to treat diseases.

Drug targets are specific molecules or pathways involved in disease progression. By inhibiting or modulating these targets, drugs can effectively treat various illnesses. Examples of drug targets include enzymes, receptors, and signaling proteins.

cancer

A disease characterized by uncontrolled cell growth and spread.

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. It arises from genetic mutations that disrupt normal cell regulation and proliferation.

diabetes

A metabolic disorder characterized by high blood sugar levels.

Diabetes is a chronic condition affecting how the body regulates blood sugar. It occurs when the pancreas doesn't produce enough insulin or when cells become resistant to insulin's effects. This leads to elevated blood glucose levels, which can damage various organs.

neurological disorders

Conditions affecting the nervous system.

Neurological disorders encompass a wide range of diseases and conditions affecting the brain, spinal cord, and nerves. They can cause diverse symptoms, such as impaired movement, sensory disturbances, cognitive decline, and mood changes.