RESEARCH: CANCER
FOLDING PROJECT #17730 PROFILE

This project studies how proteins use ion gradients to move molecules across cell membranes. These proteins are important for many bodily functions and are targets for drugs treating diseases like cancer and diabetes. By studying them, we can learn more about how these proteins work across different types of organisms.

Note: This TLDR is a simplication and may not be 100% accurate.

Projects 17711-17724 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat disease like cancer, diabetes, and neurological disorders.

These simulations will allow us to understand a universal role of ion-coupling across different families of proteins.

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Secondary active transporters

Proteins that use ions to transport molecules across cell membranes.

Secondary active transporters are crucial proteins found in all living organisms. They utilize an existing ion gradient to power the movement of various molecules across cell membranes. This process is essential for many cellular functions and makes these transporters important targets for treating diseases like cancer, diabetes, and neurological disorders.

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Ion gradient

A difference in ion concentration across a cell membrane.

An ion gradient refers to an uneven distribution of charged particles (ions) on either side of a cell membrane. This imbalance in charge is essential for various cellular processes, including nerve impulse transmission and nutrient uptake. Secondary active transporters exploit this gradient to facilitate the movement of molecules across the membrane.

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Drug targets

Molecules or cellular processes that are targeted by drugs.

Drug targets are specific molecules or cellular pathways that are involved in the development or progression of a disease. By targeting these molecules, drugs can aim to either block their function or enhance their activity, leading to therapeutic effects.

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Simulations

Computer models used to represent and study complex systems.

Simulations are powerful tools in biotechnology research that allow scientists to create virtual representations of biological processes. These models can be used to test hypotheses, explore different scenarios, and gain insights into the behavior of complex systems like proteins or entire cells.

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Cancer

A group of diseases characterized by uncontrolled cell growth.

Cancer is a broad term encompassing various diseases characterized by the uncontrolled growth and spread of abnormal cells. These cells can invade surrounding tissues and organs, leading to life-threatening complications.

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Diabetes

A metabolic disorder characterized by high blood sugar levels.

Diabetes is a chronic disease affecting how the body regulates blood sugar (glucose). In type 1 diabetes, the immune system destroys insulin-producing cells. In type 2 diabetes, the body becomes resistant to insulin or doesn't produce enough. Both types lead to high blood sugar levels, which can damage various organs over time.

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Neurological disorders

Conditions affecting the nervous system.

Neurological disorders encompass a wide range of conditions impacting the brain, spinal cord, and nerves. These disorders can affect various aspects of neurological function, including movement, sensation, cognition, and emotions.