RESEARCH: G-PROTEINS
FOLDING PROJECT #17256 PROFILE

G-proteins control important body functions like vision and muscle movement. They switch between active and inactive states depending on a molecule they bind. This project is looking at how G-proteins release a molecule called GDP, which is key to them turning on and doing their job.

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process.

G-proteins

Proteins that bind to guanine nucleotides (GDP or GTP) and regulate cellular signaling.

G-proteins are essential proteins involved in transmitting signals within cells. They act like molecular switches, turning on or off various cellular processes depending on whether they are bound to GDP or GTP. G-proteins play crucial roles in many biological functions, including vision, taste, smell, muscle contraction, and nerve transmission. Dysregulation of G-protein function can contribute to diseases.

Signaling Pathways

A series of molecular events that transmit a signal from one part of a cell to another.

Signaling pathways are intricate communication networks within cells. They allow cells to respond to external stimuli and coordinate their activities. Signals are transmitted through a cascade of protein interactions, ultimately leading to specific cellular responses like gene expression, enzyme activation, or changes in cell behavior.

GDP

Guanosine diphosphate

GDP is a molecule that serves as an energy carrier and plays a vital role in cellular processes. It's involved in the synthesis of other molecules, such as RNA and DNA, and acts as a signaling molecule in various pathways.

GTP

Guanosine triphosphate

GTP is a molecule that plays a crucial role in cellular energy transfer and signal transduction. It's involved in processes like protein synthesis, DNA replication, and cell division.