RESEARCH: G-PROTEINS
FOLDING PROJECT #17226 PROFILE

G-proteins are important for senses like sight and smell, and controlling muscle movements. They switch between active and inactive states depending on what molecule they have attached. The project relates to how G-proteins get rid of one molecule (GDP) to become active, which is a key step that can go wrong in diseases.

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process.

G-proteins

Guanine nucleotide-binding proteins

G-proteins are a family of proteins that play a crucial role in transmitting signals within cells. They act as molecular switches, cycling between active and inactive states depending on the binding of guanine nucleotides (GDP or GTP). This process is essential for regulating various cellular functions, including vision, taste, smell, muscle contraction, and neurotransmission.

Signalling pathways

A series of biochemical reactions that transmit a signal from a cell's exterior to its interior.

Signaling pathways are complex networks of molecules that relay information within and between cells. These pathways allow cells to respond to external stimuli, such as hormones, nutrients, or environmental changes. They involve a cascade of events, where one molecule activates another, ultimately leading to a specific cellular response.

GDP

Guanosine diphosphate

GDP is a nucleotide that plays a crucial role in cellular processes, particularly in signaling pathways. It acts as a precursor to GTP and is involved in the regulation of enzyme activity.

GTP

Guanosine triphosphate

GTP is a nucleotide that plays a critical role in cellular energy transfer and signaling pathways. It provides the energy required for various cellular processes, such as protein synthesis and cell division.