RESEARCH: G-PROTEINS
FOLDING PROJECT #17223 PROFILE

G-proteins are important for senses like sight and smell, as well as muscle movement and brain signals. They switch between active and inactive states based on what molecule they have bound. The project relates to understanding how G-proteins release a molecule called GDP, which is a key step in turning them active. This process can go wrong and cause diseases.

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process.

G-proteins

Guanine nucleotide-binding proteins

G-proteins are crucial signaling molecules that switch between active and inactive states based on the bound nucleotide (GDP or GTP). They regulate various cellular processes like vision, taste, olfaction, muscle contraction, and neurotransmission. Dysregulation of G-protein activity can contribute to diseases.

Signaling Pathways

A series of molecular events that transmit signals within a cell or between cells.

Signaling pathways are complex networks of molecules that relay information within and between cells. These pathways govern essential cellular functions like growth, differentiation, metabolism, and responses to stimuli. Disruptions in signaling pathways can lead to various diseases.

GDP

Guanosine diphosphate

GDP is a molecule that plays a role in cellular energy transfer and signaling. It is a nucleotide composed of guanine, ribose sugar, and two phosphate groups.

GTP

Guanosine triphosphate

GTP is a molecule involved in energy transfer and signaling processes within cells. It is a nucleotide consisting of guanine, ribose sugar, and three phosphate groups.

Disease Conditions

Abnormal states of health characterized by specific symptoms and signs.

Disease conditions are medical disorders that disrupt normal bodily functions. They can result from various factors such as genetic defects, infections, lifestyle choices, or environmental exposures.