RESEARCH: G-PROTEINS
FOLDING PROJECT #17229 PROFILE

G-proteins are like tiny switches that control important processes in our bodies, like vision and muscle movement. They work by switching between active and inactive states using molecules called GDP and GTP. This project is investigating how G-proteins release GDP, a crucial step in their activation process. Understanding this could help us treat diseases caused by G-protein malfunction.

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process.

G-proteins

Guanine nucleotide-binding proteins involved in signal transduction.

G-proteins are a type of protein that act as molecular switches within cells. They bind to guanine nucleotides (GDP and GTP) and change shape depending on which nucleotide is bound. This shape change allows them to activate or deactivate other proteins, ultimately controlling various cellular processes like vision, taste, smell, muscle contraction, and nerve signaling.

Signalling Pathways

Series of molecular interactions leading to a specific cellular response.

Signaling pathways are complex chains of events within cells that transmit signals from outside the cell to the inside. These signals can trigger various responses, such as changes in gene expression, protein synthesis, or cell behavior. G-proteins play a crucial role in many signaling pathways by relaying information and activating downstream targets.

GDP

Guanosine diphosphate

GDP is a molecule that carries energy within cells. It's involved in various metabolic processes and acts as a building block for other molecules like RNA.

GTP

Guanosine triphosphate

GTP is a molecule that carries energy within cells. It's involved in various metabolic processes and plays a crucial role in protein synthesis.

Disease Conditions

Conditions that disrupt normal physiological function.

Disease conditions are abnormal states in the body that interfere with proper functioning. They can result from various factors like genetic mutations, infections, lifestyle choices, or environmental exposures.