RESEARCH: G-PROTEINS
FOLDING PROJECT #17209 PROFILE

G-proteins are like switches that control many important body functions. They use a molecule called GDP to turn off and GTP to turn on. This project is looking at how G-proteins get rid of GDP so they can switch to the 'on' position, because when this process goes wrong, it can cause diseases.

G-proteins play central role in various signalling pathways involved in vision, taste, oflaction, muscle contraction and neurotransmission.

G-proteins regulate these signalling pathways by switching between 'active' and 'inactive' states, dictated by the type nucleotide bound to their active site.

When bound to gaunosine dinucleotide (GDP), G-proteins adopt inactive state.

Dissociation of GDP and subsequent binding of gaunosine trinucleotide (GTP) activates G-proteins, which in turn activate downstream signalling pathways.

GDP dissociation is the rate limiting step in activation of G-proteins and misregulation of this process can often lead to disease conditions.

in this project, we are studying the mechanism of GDP dissociation process.

G-proteins

Guanine nucleotide-binding proteins

G-proteins are a family of proteins that act as molecular switches in cells. They play a crucial role in transmitting signals from cell surface receptors to intracellular targets. This process is essential for various cellular functions, including vision, taste, olfaction, muscle contraction, and neurotransmission.

GDP

Guanosine diphosphate

GDP is a molecule that serves as the inactive form of G-proteins. When bound to a G-protein, it keeps the protein in an inactive state.

GTP

Guanosine triphosphate

GTP is a molecule that activates G-proteins. When bound to a G-protein, it triggers a conformational change, activating the protein and allowing it to transmit signals.

Signalling pathways

A series of molecular events that transmit a signal from one part of a cell to another.

Signaling pathways are complex networks within cells that relay information from external stimuli to intracellular targets. They are essential for coordinating cellular responses, controlling growth and development, and maintaining homeostasis.

Disease conditions

Abnormal states of health characterized by specific symptoms and signs.

Disease conditions arise from disruptions in normal cellular functions, often caused by genetic mutations, environmental factors, or infections. These abnormalities can lead to a wide range of symptoms and impairments.