RESEARCH: POLYMERASE
FOLDING PROJECT #16706 PROFILE

This project uses computer simulations to study how proteins fold. One part looks at how a protein called RNA polymerase folds, which is important for bacteria and a target for antibiotics. The other part studies how a helper protein called Hsp70 helps other proteins fold correctly.

This series of GPU projects to simulation the Bacterial RNA Polymerase.

16700-16706: Simulation of E.

coli RNA Polymerase Trigger Loop folding, the target for antibiotics (CBR compounds). 16750-16755: Simulation of folding of client proteins with a chaperone Hsp70.

GPU

Graphics Processing Unit

A specialized electronic circuit designed to rapidly manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display device.

Bacterial RNA Polymerase

An enzyme complex responsible for transcribing DNA into RNA in bacteria.

Bacterial RNA polymerase is a vital enzyme that plays a crucial role in gene expression. It binds to specific DNA sequences called promoters and synthesizes RNA molecules complementary to the DNA template. This process is essential for producing proteins and regulating cellular functions.

Antibiotics

Drugs that inhibit the growth of or kill bacteria.

Antibiotics are a class of antimicrobial drugs used to treat bacterial infections. They work by targeting specific mechanisms essential for bacterial survival, such as cell wall synthesis, protein production, or DNA replication. The judicious use of antibiotics is crucial to prevent antibiotic resistance.

CBR compounds

Chemically-Based Receptor compounds

CBR compounds are a class of molecules designed to interact with specific receptors in the body. They are often used as drug candidates in research and development.

Hsp70

Heat Shock Protein 70

Hsp70 is a family of proteins that play a crucial role in assisting the folding and assembly of other proteins. They are particularly important under stress conditions, such as heat shock, where they help prevent protein misfolding.

Chaperone

A protein that assists in the folding and assembly of other proteins.

Chaperones are essential cellular proteins that help guide the folding of newly synthesized proteins into their correct three-dimensional shapes. They prevent misfolding and aggregation, ensuring proper protein function.