RESEARCH: POLYMERASE
FOLDING PROJECT #16701 PROFILE

This project uses powerful computer graphics cards (GPUs) to simulate how the RNA polymerase in E. coli bacteria folds its 'trigger loop'. This loop is a target for antibiotics called CBR compounds, so understanding how it works can help us develop new and better drugs.

This series of GPU projects to simulation the Bacterial RNA Polymerase.

16700,16701: Simulation of E.

coli RNA Polymerase Trigger Loop folding, the target for antibiotics (CBR compounds).

GPU

Graphics Processing Unit

A specialized electronic circuit designed to rapidly manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display.

Bacterial RNA Polymerase

An enzyme responsible for transcribing DNA into RNA in bacteria.

Bacterial RNA polymerase is a crucial enzyme that plays a vital role in gene expression. It binds to DNA and synthesizes RNA molecules using the DNA sequence as a template. This process is essential for creating messenger RNA (mRNA), which carries genetic information from DNA to ribosomes, where proteins are synthesized.

E.coli

Escherichia coli

A common type of bacteria found in the intestines of humans and animals. It is often used as a model organism in scientific research due to its rapid growth and ease of manipulation.

RNA Polymerase Trigger Loop

A specific region within the RNA polymerase enzyme that plays a role in initiation and elongation of transcription.

The trigger loop is a flexible structure within the RNA polymerase enzyme. It changes shape during the process of transcription, helping to bind to DNA and initiate the synthesis of RNA molecules.

Antibiotics

Drugs used to treat bacterial infections.

Antibiotics are medications that kill or inhibit the growth of bacteria. They work by targeting specific processes essential for bacterial survival, such as cell wall synthesis, protein production, or DNA replication.

CBR Compounds

Carbon-based Receptor Binding compounds

CBR compounds are a class of drugs designed to bind to specific receptors on cells. They are used in various therapeutic areas, including infectious diseases and cancer.