RESEARCH: POLYMERASE
FOLDING PROJECT #16755 PROFILE

This project uses computer simulations to study how bacteria work at the molecular level. One part looks at how antibiotics target a specific part of bacterial RNA polymerase, which is essential for making proteins. Another part simulates how special helper proteins called chaperones assist in folding other proteins correctly.

This series of GPU projects to simulation the Bacterial RNA Polymerase.

16700,16701: Simulation of E.

coli RNA Polymerase Trigger Loop folding, the target for antibiotics (CBR compounds). 16750-16755: Simulation of folding of client proteins with a chaperone Hsp70.

GPU

Graphics Processing Unit

A specialized electronic circuit designed to rapidly manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display device.

RNA Polymerase

An enzyme responsible for synthesizing RNA from a DNA template.

RNA polymerase is an essential enzyme that plays a crucial role in gene expression. It reads the genetic information encoded in DNA and uses it to create a complementary RNA molecule. This RNA molecule can then be used as a template for protein synthesis.

Antibiotics

Drugs that inhibit the growth or kill bacteria.

Antibiotics are medications used to treat bacterial infections. They work by interfering with various processes essential for bacterial survival and replication, such as cell wall synthesis or protein production.

CBR Compounds

Compounds that target bacterial ribosomes.

CBR compounds are a class of antibiotics that specifically target bacterial ribosomes. Ribosomes are essential cellular structures responsible for protein synthesis.

Hsp70

Heat Shock Protein 70

Hsp70 is a family of chaperone proteins that play a crucial role in assisting other proteins to fold correctly and preventing their aggregation.

Chaperone

A protein that assists in the folding or unfolding of other proteins.

Chaperones are essential proteins that assist other proteins in achieving their correct three-dimensional structure. They prevent misfolding and aggregation, ensuring proper protein function.