RESEARCH: POLYMERASE
FOLDING PROJECT #16752 PROFILE

This project uses powerful computer simulations to study how bacteria work. One part looks at how a protein called RNA polymerase folds, which is important for making bacterial DNA into RNA and a target for some antibiotics. Another part studies how proteins called chaperones help other proteins fold correctly.

This series of GPU projects to simulation the Bacterial RNA Polymerase.

16700,16701: Simulation of E.

coli RNA Polymerase Trigger Loop folding, the target for antibiotics (CBR compounds). 16750-16755: Simulation of folding of client proteins with a chaperone Hsp70.

GPU

Graphics Processing Unit

A specialized electronic circuit designed to rapidly manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display. GPUs are commonly used in computer graphics, gaming, and scientific computing.

Bacterial RNA Polymerase

The enzyme complex responsible for transcribing DNA into RNA in bacteria.

Bacterial RNA polymerase is a crucial enzyme that reads the genetic information stored in DNA and creates messenger RNA (mRNA). This mRNA then serves as a template for protein synthesis. Understanding how bacterial RNA polymerase works is essential for developing new antibiotics that can target this process.

Antibiotics

Drugs that kill or inhibit the growth of bacteria.

Antibiotics are medications used to treat bacterial infections. They work by interfering with various processes essential for bacterial survival and replication. The discovery and development of antibiotics have revolutionized healthcare, saving countless lives.

CBR Compounds

Chemically Biologically Responsive compounds

CBR compounds are a class of molecules designed to interact with specific biological targets. They often exhibit responsiveness to changes in their environment, such as pH or temperature.

Hsp70

Heat shock protein 70

Hsp70 is a family of chaperone proteins that play a crucial role in cellular stress response. They assist in folding and stabilizing other proteins, preventing their aggregation.

Chaperone

A protein that assists in the folding and assembly of other proteins.

Chaperone proteins act as cellular guides, helping other proteins fold into their correct shapes. They prevent misfolding and aggregation, ensuring proper protein function.