RESEARCH: POLYMERASE
FOLDING PROJECT #16750 PROFILE

This project uses computer simulations to study how bacteria work. It looks at how a key protein in bacteria folds, which is important for their survival and can be targeted by antibiotics. It also studies how another protein helps other proteins fold correctly.

This series of GPU projects to simulation the Bacterial RNA Polymerase.

16700,16701: Simulation of E.

coli RNA Polymerase Trigger Loop folding, the target for antibiotics (CBR compounds). 16750-16755: Simulation of folding of client proteins with a chaperone Hsp70.

GPU

Graphics Processing Unit

A specialized electronic circuit designed to rapidly manipulate and alter memory to accelerate the creation of images in a frame buffer intended for output to a display device.

Bacterial RNA Polymerase

The enzyme responsible for transcribing DNA into RNA in bacteria.

Bacterial RNA Polymerase is a crucial enzyme that plays a vital role in protein synthesis. It binds to specific DNA regions called promoters and uses them as starting points to synthesize RNA molecules from a DNA template.

Antibiotics

Drugs that kill or inhibit the growth of bacteria.

Antibiotics are a class of medications used to treat bacterial infections. They work by interfering with various processes essential for bacterial survival and replication.

CBR compounds

Compounds targeting bacterial RNA Polymerase

CBR compounds are a type of drug being researched for their ability to target and inhibit bacterial RNA polymerase. By interfering with this essential enzyme, these compounds aim to prevent bacterial growth and treat infections.

Hsp70

Heat Shock Protein 70

Hsp70 is a family of chaperone proteins that play a crucial role in cellular stress response. They assist in the folding and assembly of other proteins, preventing aggregation and promoting proper protein function.

Chaperone

A protein that assists in the folding and assembly of other proteins.

Chaperone proteins are essential for maintaining cellular health. They act as guides and helpers, ensuring that newly synthesized proteins fold correctly and function properly.