RESEARCH: COVID-19
FOLDING PROJECT #16609 PROFILE

This project uses computer simulations to study how SARS-CoV-2's nsp12 and nsp14 proteins work. They'll test existing drugs, like Ribirine, to see if they can block these proteins and stop the virus from replicating.

This series of GPU projects to simulation the Nonstructural protein 12 (nsp12) and Nonstructural protein 14 (nsp14) complexes.

We will screen existing FDA-approved NTP analog drugs (e.g.

Ribirine).

We aim to repurpose drugs that can inhibit SARS-CoV-2 replication 16600: Nonstructural protein 14 and 10 (nsp14-ExoN & nsp 10) of the SARS-CoV-2 in complex with a short nascent RNA containing Cladribine at 3'-terminal. 16602: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP in active site 16603: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16604: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and GTP. 16605: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16606: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16607: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16608: RdRp and helicase of SARS-CoV-2 in complex with dsRNA 16609: RdRp and helicase of SARS-CoV-2 in complex with dsRNA.

Nonstructural protein 12

A viral protein involved in RNA replication.

Nonstructural protein 12 (nsp12) is a crucial enzyme found in coronaviruses like SARS-CoV-2. It's responsible for copying the virus's genetic material, RNA, which is essential for the virus to replicate and spread.

Nonstructural protein 14

A viral protein involved in RNA proofreading and repair.

Nonstructural protein 14 (nsp14) plays a vital role in correcting errors during the replication of the coronavirus's RNA genome. It acts like a proofreader, ensuring the genetic information is copied accurately.

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. It's a type of coronavirus that primarily affects the respiratory system, causing symptoms like fever, cough, and difficulty breathing.

NTP

Nucleoside Triphosphate

NTPs are molecules essential for DNA and RNA synthesis. They serve as building blocks for genetic material in cells.

FDA

Food and Drug Administration

The FDA is a US government agency responsible for ensuring the safety and effectiveness of drugs, medical devices, and other products before they are available to the public.

RdRp

RNA-dependent RNA Polymerase

RdRp is an enzyme crucial for replicating RNA genomes in viruses like SARS-CoV-2. It reads the viral RNA and synthesizes a new complementary strand.

dsRNA

Double-stranded RNA

dsRNA consists of two complementary RNA strands bound together. It plays a role in various biological processes, including viral replication and gene regulation.