RESEARCH: COVID-19
FOLDING PROJECT #16607 PROFILE

This project uses computer simulations to study how two important proteins (nsp12 and nsp14) from the SARS-CoV-2 virus work. Researchers will test if existing drugs, like Ribirine, can block these proteins and stop the virus from replicating. This could lead to new treatments for COVID-19.

Note: This TLDR is a simplication and may not be 100% accurate.

This series of GPU projects to simulation the Nonstructural protein 12 (nsp12) and Nonstructural protein 14 (nsp14) complexes.

We will screen existing FDA-approved NTP analog drugs (e.g.

Ribirine).

We aim to repurpose drugs that can inhibit SARS-CoV-2 replication 16600: Nonstructural protein 14 and 10 (nsp14-ExoN & nsp 10) of the SARS-CoV-2 in complex with a short nascent RNA containing Cladribine at 3'-terminal. 16602: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP in active site 16603: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16604: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and GTP. 16605: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16606: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP. 16607: Nonstructural protein 12, 7 and 8 of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP.

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Nonstructural protein 12

Protein involved in RNA replication of viruses.

Nonstructural protein 12 (nsp12) is a vital enzyme found in coronaviruses like SARS-CoV-2. It plays a crucial role in replicating the virus's RNA genetic material, allowing the virus to spread and infect new cells.

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Nonstructural protein 14

Protein involved in RNA editing and proofreading during viral replication.

Nonstructural protein 14 (nsp14) is another important protein found in coronaviruses. It helps to correct errors made during the process of copying the virus's RNA genome, ensuring accurate replication.

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Complex

A group of interacting molecules, often proteins, working together.

In biochemistry, a complex refers to two or more molecules that come together and interact to perform a specific function. These interactions can be temporary or long-lasting.

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RNA

A nucleic acid that carries genetic information.

Ribonucleic acid (RNA) is a crucial molecule found in all living cells. It plays a vital role in protein synthesis and carries genetic information from DNA to the ribosomes, where proteins are made.

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ATP

Adenosine triphosphate

ATP (adenosine triphosphate) is the primary energy currency of cells. It stores and releases chemical energy needed for various cellular processes, such as muscle contraction, nerve impulse transmission, and protein synthesis.

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GTP

Guanosine triphosphate

GTP (guanosine triphosphate) is a molecule similar to ATP. It plays a crucial role in various cellular processes, including protein synthesis, signal transduction, and cell division.

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SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. It is a respiratory virus that can cause severe illness and death.

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Cladribine

A nucleoside analog used to treat multiple sclerosis and HIV.

Cladribine is a medication used to treat various immune system disorders. It works by interfering with the replication of certain cells involved in the disease process.

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Ribavirin

An antiviral medication used to treat hepatitis C and respiratory syncytial virus (RSV).

Ribavirin is a widely used antiviral drug that inhibits the replication of certain viruses. It is effective against various RNA viruses, including those causing hepatitis C and RSV.