RESEARCH: COVID-19
FOLDING PROJECT #16602 PROFILE

This project uses computer simulations to study how certain drugs might block the SARS-CoV-2 virus. Scientists will look at proteins like nsp12, nsp14, and how they interact with RNA during viral replication. The goal is to find existing drugs that can be repurposed to treat COVID-19.

Note: This TLDR is a simplication and may not be 100% accurate.

This series of GPU projects to simulation the Nonstructural protein 12 (nsp12) and Nonstructural protein 14 (nsp14) complexes.

We will screen existing FDA-approved NTP analog drugs (e.g.

Ribirine).

We aim to repurpose drugs that can inhibit SARS-CoV-2 replication 16600: Nonstructural protein 14 and 10 (nsp14-ExoN & nsp 10) of the SARS-CoV-2 in complex with a short nascent RNA containing Cladribine at 3'-terminal. 16602: Nonstructural protein 12, 7 and 8of the SARS-CoV-2 in complex with a short nascent RNA , template RNA and ATP in active site.

---

Nonstructural protein 12

A protein crucial for viral replication.

Nonstructural protein 12 (nsp12) is an essential enzyme found in SARS-CoV-2. It's responsible for replicating the virus's genetic material, making copies of its RNA to spread infection.

---

Nonstructural protein 14

A protein involved in proofreading viral RNA replication.

Nonstructural protein 14 (nsp14) plays a role in ensuring the accuracy of SARS-CoV-2's RNA replication. It acts like an editor, correcting errors made during the copying process.

---

FDA

Food and Drug Administration

The FDA is a government agency responsible for ensuring the safety and effectiveness of medications and other healthcare products in the United States.

---

NTP analog drugs

Medicines that mimic the structure of nucleoside triphosphates (NTPs).

Nucleoside triphosphate analogs (NTP analogs) are a type of antiviral drug. They interfere with the replication process of viruses by acting like faulty building blocks in their genetic material.

---

Ribirine

A nucleoside analog with antiviral activity.

Ribirine is a nucleoside analog that can inhibit the replication of certain viruses. It's been studied as a potential treatment for various viral infections.

---

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. It's a type of coronavirus that spreads easily through respiratory droplets.

---

Cladribine

A nucleoside analog antiviral medication.

Cladribine is a nucleoside analog used to treat certain types of cancer and viral infections. It works by interfering with the replication of rapidly dividing cells.

---

ATP

Adenosine triphosphate

ATP is the primary energy currency of cells. It's used to power various cellular processes, such as muscle contraction and protein synthesis.