RESEARCH: CANCER
FOLDING PROJECT #12131 PROFILE

Proteins are like tiny machines that need to fold into specific shapes to work correctly. Sometimes mutations (changes) in the protein's instructions can mess up this folding, causing diseases like cancer and Alzheimer's. This project aims to study how these mutations affect protein folding so we can better understand and treat these diseases.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

A large biomolecule consisting of chains of amino acids.

Proteins are essential molecules found in all living organisms. They perform a wide range of functions, including catalyzing biochemical reactions, transporting molecules, and providing structural support. The sequence and folding of amino acids determine the specific function of each protein.

Peptide

A short chain of amino acids linked together by peptide bonds.

Peptides are smaller chains of amino acids. They often act as signaling molecules or precursors to larger proteins.

Misfolding

The process by which a protein fails to assume its correct three-dimensional shape.

Misfolding occurs when a protein does not fold properly into its intended shape. This can lead to the protein losing its function and potentially causing disease.

Mutation

A permanent change in the DNA sequence.

Mutations are alterations in the genetic code. They can be spontaneous or induced by environmental factors. Mutations can have various effects, including changes in protein structure and function.

Cancer

A group of diseases characterized by uncontrolled cell growth.

Cancer is a group of diseases where abnormal cells grow and spread uncontrollably. This can lead to tumors and damage to various organs.

Alzheimer's

A progressive neurodegenerative disease that affects memory and cognitive function.

Alzheimer's disease is a brain disorder that causes a gradual decline in memory, thinking, and behavior. It is the most common cause of dementia.