RESEARCH: CANCER
FOLDING PROJECT #12127 PROFILE

Proteins sometimes fold incorrectly, causing diseases like cancer and Alzheimer's. This project studies how changes in protein code affect how they fold to better understand and predict these issues.

Note: This TLDR is a simplication and may not be 100% accurate.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

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Protein

Large biomolecule essential for various bodily functions.

Proteins are complex molecules made up of amino acids. They perform a wide range of functions in living organisms, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.

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Misfolding

Failure of a protein to assume its correct three-dimensional shape.

Misfolding occurs when a protein does not fold into its proper shape. This can disrupt the protein's function and lead to various diseases.

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Peptide

Short chain of amino acids linked together.

Peptides are short chains of amino acids. They often serve as building blocks for larger proteins.

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Mutations

Changes in the DNA sequence.

Mutations are alterations in the genetic code. They can be caused by errors during DNA replication or exposure to mutagens.

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Conformation

Three-dimensional shape of a molecule.

Conformation refers to the specific arrangement of atoms in a molecule. It is crucial for the function of proteins and other biomolecules.

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Cancer

Uncontrolled cell growth.

Cancer is a disease characterized by the uncontrolled growth and spread of abnormal cells. It can affect various parts of the body.

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Alzheimer's

Alzheimer's disease (AD)

Alzheimer's disease is a progressive neurodegenerative disorder that causes memory loss, cognitive decline, and behavioral changes.