RESEARCH: CANCER
FOLDING PROJECT #12126 PROFILE

Proteins need to fold into specific shapes to work right. Sometimes changes in a protein's code can mess up this folding, causing diseases like cancer and Alzheimer's. This project is trying to figure out how these changes affect how proteins fold so we can better understand and treat these diseases.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

Large biomolecules essential for various cellular functions.

Proteins are complex molecules found in all living things. They perform many vital roles, such as building and repairing tissues, transporting substances, and catalyzing chemical reactions.

Misfolding

An incorrect three-dimensional shape adopted by a protein.

Protein misfolding happens when a protein doesn't fold into its correct shape. This can lead to problems with the protein's function and cause diseases.

Mutation

A permanent change in the DNA sequence.

Mutations are changes in the genetic code. They can be caused by errors during DNA replication or exposure to mutagens like radiation. Mutations can have various effects on organisms, including no effect, beneficial effects, or harmful effects.

Alzheimer's

A progressive neurodegenerative disease.

Alzheimer's disease is a brain disorder that causes memory loss, thinking problems, and behavioral changes. It is the most common cause of dementia.

Cancer

Uncontrolled cell growth and spread.

Cancer is a group of diseases characterized by the abnormal growth and spread of cells. It can affect any part of the body.