RESEARCH: PARKINSONS
FOLDING PROJECT #19020 PROFILE

This project uses computer simulations to study the glycine transporter, a protein that controls brain activity. Glycine helps calm nerves, and problems with this transporter can cause diseases like schizophrenia. Understanding how it works will help scientists develop better drugs.

Note: This TLDR is a simplication and may not be 100% accurate.

These projects contains simulations of the glycine transporter, the protein responsible for terminating neurotransmission in neurons.

Glycine is a major inhibitory neurontramitter of the spinal cord and brain stem.

Malfunctions in the glycine transporter have been assoicated with neurological diseases including schizophrenia and hyperekplexia.

Our goal in performing these simulations is to understand how the ions are coupled with substrate transport, which will enable better design of drugs targetting the glycine transporter.

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glycine transporter

A protein responsible for transporting glycine across cell membranes.

The glycine transporter is a crucial protein found in neurons that helps regulate the levels of glycine, an inhibitory neurotransmitter. It works by moving glycine across the cell membrane, effectively terminating its signaling and allowing for precise control of neuronal activity. Dysfunctions in this transporter have been linked to various neurological disorders, highlighting its importance in maintaining brain health.

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neurotransmission

The process of transmitting signals between neurons.

Neurotransmission is the fundamental mechanism by which our nervous system communicates. It involves the release of chemical messengers called neurotransmitters from one neuron and their reception by another neuron across a tiny gap called the synapse. This process allows for the transmission of information throughout the brain and body, enabling us to think, feel, and act.

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neurons

Specialized cells that transmit information throughout the body.

Neurons are the fundamental units of our nervous system. These highly specialized cells receive, process, and transmit information through electrical and chemical signals. They form complex networks within the brain and throughout the body, allowing us to perceive our surroundings, think, learn, and control our movements.

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schizophrenia

A chronic mental disorder characterized by disturbances in thought, perception, emotion, and behavior.

Schizophrenia is a complex brain disorder that affects a person's ability to think, feel, and behave clearly. People with schizophrenia may experience hallucinations, delusions, disorganized thinking, and difficulty with social interactions. It is a chronic condition that requires ongoing treatment and support.

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hyperekplexia

A rare neurological disorder characterized by exaggerated startle reflexes.

Hyperekplexia is a genetic disorder that causes individuals to have unusually strong and involuntary muscle contractions in response to sudden stimuli. These startle reactions can be severe and potentially dangerous, leading to falls or injuries.

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drugs

Substances that have a physiological effect on the body.

Drugs are chemical substances that can alter the way our bodies function. They work by interacting with specific receptors and molecules in the body, triggering various effects. Drugs can be used for therapeutic purposes to treat diseases or manage symptoms, but they can also be misused or abused.