RESEARCH: CANCER
FOLDING PROJECT #12925 PROFILE

Proteins need to fold correctly to work. Sometimes changes in their DNA (mutations) mess up this folding and cause diseases like cancer or Alzheimer's. This project looks at how specific mutations affect how tightly packed proteins are, helping us understand why some proteins break down easily when it's hot.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

This project is concerned with characterizing the effect of specific mutations on the hydrophobic packing of proteins at different temperatures to predict thermostability.

Protein

A large biomolecule consisting of chains of amino acids.

Proteins are essential molecules found in all living organisms. They perform a wide variety of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.

Misfolding

The failure of a protein to fold into its correct three-dimensional structure.

Protein misfolding occurs when a protein does not achieve its proper shape. This can disrupt the protein's function and lead to various diseases.

Mutation

A permanent change in the DNA sequence.

Mutations are alterations in the genetic code. They can be caused by various factors and may have diverse effects on an organism.

Cancer

A disease characterized by the uncontrolled growth and spread of abnormal cells.

Cancer is a group of diseases involving abnormal cell growth. It can affect various organs and tissues in the body.

Alzheimer's

A progressive neurodegenerative disease that affects memory and cognitive function.

Alzheimer's disease is a brain disorder that causes memory loss, thinking problems, and behavioral changes. It is the most common cause of dementia.