RESEARCH: CANCER
FOLDING PROJECT #12922 PROFILE

Proteins need to fold correctly to work. Sometimes changes in the protein's code mess up this folding, causing diseases like cancer and Alzheimer's. This project looks at how specific changes in a protein's code affect its stability at different temperatures.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

This project is concerned with characterizing the effect of specific mutations on the hydrophobic packing of proteins at different temperatures to predict thermostability.

Protein

Large biomolecule composed of amino acids.

Proteins are essential macromolecules that perform a vast array of functions in living organisms. They act as catalysts, structural components, transporters, and signaling molecules. Their intricate three-dimensional structures enable them to interact specifically with other molecules, facilitating vital biological processes.

Misfolding

Failure of a protein to achieve its correct three-dimensional conformation.

Protein misfolding is a phenomenon where a protein fails to adopt its proper three-dimensional shape. This can occur due to genetic mutations, environmental stress, or other factors. Misfolded proteins often lose their function and can aggregate, leading to diseases like Alzheimer's and Parkinson's.

Mutations

Changes in the DNA sequence.

Mutations are alterations in the DNA sequence that can result in changes to protein structure and function. These changes can be inherited or acquired during an organism's lifetime. Mutations play a crucial role in evolution and can contribute to genetic diversity.

Cancer

Uncontrolled cell growth and proliferation.

Cancer is a group of diseases characterized by abnormal cell growth and division. These cells can invade surrounding tissues and spread to other parts of the body (metastasis). Cancer is caused by various factors, including genetic mutations, environmental exposures, and lifestyle choices.

Alzheimer's

Progressive neurodegenerative disorder.

Alzheimer's disease is a chronic neurodegenerative disorder that affects memory, thinking, and behavior. It is characterized by the accumulation of amyloid plaques and tau tangles in the brain, leading to neuronal damage and cell death.