RESEARCH: CANCER
FOLDING PROJECT #12923 PROFILE

Proteins are like tiny machines with specific shapes. Sometimes, changes in their instructions (mutations) can make them fold wrong, causing diseases like cancer and Alzheimer's. This project studies how these changes affect the stability of proteins at different temperatures.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

This project is concerned with characterizing the effect of specific mutations on the hydrophobic packing of proteins at different temperatures to predict thermostability.

Protein

A large biomolecule composed of amino acids linked in a chain.

Proteins are essential macromolecules that perform a vast array of functions in living organisms. They act as catalysts, structural components, transporters, and signaling molecules. The precise sequence of amino acids in a protein determines its three-dimensional structure and function.

Misfolding

The incorrect folding of a protein into its native structure.

Protein misfolding is a phenomenon where a protein fails to adopt its correct three-dimensional shape. This can occur due to genetic mutations, environmental factors, or errors during the protein synthesis process. Misfolded proteins can aggregate, lose their function, and contribute to various diseases.

Mutations

Permanent changes in the DNA sequence.

Mutations are alterations in the genetic code. They can be spontaneous or induced by external factors like radiation. Mutations can have various effects on organisms, ranging from harmless to detrimental. Some mutations can lead to diseases.

Cancer

A group of diseases characterized by uncontrolled cell growth and spread.

Cancer is a complex group of diseases involving the abnormal proliferation of cells. This uncontrolled growth can lead to the formation of tumors and the invasion of surrounding tissues. Cancer can affect various organs and systems in the body.

Alzheimer's

A progressive neurodegenerative disease.

Alzheimer's disease is a chronic brain disorder that gradually impairs cognitive function, including memory, thinking, and behavior. It is characterized by the accumulation of abnormal protein deposits in the brain.