RESEARCH: MEMBRANE TRANSPORT
FOLDING PROJECT #17945 PROFILE

The project relates to proteins that use ions to move molecules across cell membranes. These proteins are important for many processes and are being studied to develop new drugs.

Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

Secondary active transporters

Proteins that use ion gradients to transport molecules across cell membranes.

Secondary active transporters are essential proteins found in all living organisms. They work by using the energy from an existing ion gradient to move other molecules across cell membranes. This process is vital for various cellular functions, including nutrient uptake, waste removal, and signal transduction. Many secondary active transporters are also drug targets for treating diseases like cancer, diabetes, and neurological disorders.

Ion gradient

A difference in ion concentration across a cell membrane.

An ion gradient is a separation of electrically charged particles (ions) between two areas. In cells, this often refers to a difference in ion concentration across the cell membrane. This gradient creates potential energy that can be used to drive various cellular processes, including transporting molecules across the membrane.

Drug targets

Molecules or biological pathways that are targeted by drugs to treat diseases.

Drug targets are specific molecules or processes within the body that pharmaceutical companies aim to influence with medications. By targeting these specific areas, drugs can effectively treat various diseases and conditions.

Simulations

Computer programs that mimic real-world processes or systems.

Simulations are powerful tools used in various scientific fields to study complex systems and phenomena. By creating computer models that replicate real-world interactions, researchers can gain insights into how things work, test hypotheses, and predict outcomes.