RESEARCH: CANCER
FOLDING PROJECT #17805 PROFILE

This project studies BAX, a protein important for cell death in lymphoma. It's similar to another protein studied before, but this one changes shape dramatically when activated. This makes understanding it harder, but could lead to new cancer treatments.

BAX apoptotic protein --- a drug target in lymphoma. This is a homologous (i.e shares some structures) protein to BCL in projects 17800-03 --- as in there, I am testing adaptive sampling strategies --- this project is 'vanilla' (i.e.

no adaptive algorithm) and the problem here is probably much harder than in the previous project, this particular protein experiences 'activation' which is a massive structural change, a long tail unbinds and extends away from the protein.

BAX apoptotic protein

A pro-apoptotic protein involved in programmed cell death.

BAX is a protein that plays a crucial role in triggering apoptosis, the process of programmed cell death. It is found to be dysregulated in various cancers, including lymphoma. Research focuses on BAX as a potential drug target for cancer therapies.

BCL

Bcl-2 family of proteins regulating apoptosis.

The Bcl-2 protein family consists of various proteins that play a critical role in controlling cell death (apoptosis). Some members promote cell survival, while others, like BAX, induce apoptosis. Understanding the interactions within this family is crucial for developing targeted cancer therapies.

Adaptive Sampling

A technique for selecting protein structures in simulations.

Adaptive sampling is a computational method used to improve the efficiency of protein modeling simulations. It involves dynamically adjusting the selection criteria for protein structures during simulations, focusing on regions that are more relevant for understanding protein function or folding.