Folding.LAR.Systems Folding.LAR.Systems Folding.LAR.Systems Folding.LAR.Systems
Research section Research projects and references
  1. Projects
  2. Research Project Folding Profile

Research: CANCER Folding Project #15242

Project #15242 overview

Project Summary AI Beta

The project studies how PTCH1, a protein, moves cholesterol to control cancer-causing signals. When PTCH1 doesn't work right, it can lead to cancers like medulloblastoma and basal cell carcinoma. Understanding this process could help develop new cancer treatments.
Automated summary; simplified and may not be fully accurate.

Project team

Manager(s)
Eric Giavedoni
Institution
University of Illinois at Urbana-Champaign

Work unit

Atoms
229,370
Core
0x27
Status
Beta
Source material

Official Project Description

This project aims to elucidate the cholesterol transport mechanism in PTCH1, a transmembrane protein responsible for inhibiting SMO in the absence of SHH in the hedgehog signaling pathway by reducing access to ciliary membrane cholesterol.

Dysregulation of this pathway (such as the inability of PTCH1 to transport cholesterol and thereby inhibit SMO) has been linked to various cancers, including medulloblastoma and basal cell carcinoma.

Thus, understanding the mechanisms behind PTCH1 cholesterol transport will allow for therapeutic treatments to target these cancers.

Performance data

Hardware Performance for Project 15242

Compare community-sampled Folding@Home output for the GPUs and CPUs processing this project.

Data as of Wednesday, 04 November 2026 07:45:43

GPU PPD Averages

Rank
Project 		Model Name
Folding@Home Identifier 		Make
Brand 		GPU
Model 		PPD
Average 		Points WU
Average 		WUs Day
Average 		WU Time
Average
1 GeForce RTX 5090
GB202 [GeForce RTX 5090]		 Nvidia GB202 22,885,810 158,505 144.39 0 hrs 10 mins
2 GeForce RTX 4090
AD102 [GeForce RTX 4090]		 Nvidia AD102 22,205,173 208,746 106.37 0 hrs 14 mins
3 GeForce RTX 4070 SUPER
AD104 [GeForce RTX 4070 SUPER]		 Nvidia AD104 17,773,352 158,505 112.13 0 hrs 13 mins
4 GeForce RTX 5070 Ti
GB203 [GeForce RTX 5070 Ti]		 Nvidia GB203 16,827,118 158,505 106.16 0 hrs 14 mins
5 GeForce RTX 4080 SUPER
AD103 [GeForce RTX 4080 SUPER]		 Nvidia AD103 16,257,303 158,505 102.57 0 hrs 14 mins
6 GeForce RTX 4080
AD103 [GeForce RTX 4080]		 Nvidia AD103 15,627,697 1,127,190 13.86 1 hrs 44 mins
7 GeForce RTX 4070 Ti
AD104 [GeForce RTX 4070 Ti]		 Nvidia AD104 13,548,532 158,505 85.48 0 hrs 17 mins
8 RTX PRO 4000 Blackwell
GB203GL [RTX PRO 4000 Blackwell]		 Unknown GB203GL 11,930,085 158,505 75.27 0 hrs 19 mins
9 GeForce RTX 5070
GB205 [GeForce RTX 5070]		 Nvidia GB205 11,520,829 158,505 72.68 0 hrs 20 mins
10 GeForce RTX 4070
AD104 [GeForce RTX 4070]		 Nvidia AD104 7,754,095 158,505 48.92 0 hrs 29 mins
11 GeForce RTX 3080
GA102 [GeForce RTX 3080]		 Nvidia GA102 6,744,486 158,505 42.55 0 hrs 34 mins
12 GeForce RTX 3080 Lite Hash Rate
GA102 [GeForce RTX 3080 Lite Hash Rate]		 Nvidia GA102 6,733,059 158,505 42.48 0 hrs 34 mins
13 GeForce RTX 5060 Ti
GB206 [GeForce RTX 5060 Ti]		 Nvidia GB206 5,952,086 158,505 37.55 0 hrs 38 mins
14 GeForce RTX 5060
GB206 [GeForce RTX 5060]		 Nvidia GB206 5,426,494 158,505 34.24 0 hrs 42 mins
15 GeForce RTX 3070
GA104 [GeForce RTX 3070]		 Nvidia GA104 4,304,891 158,505 27.16 0 hrs 53 mins
16 GeForce RTX 4060
AD107 [GeForce RTX 4060]		 Nvidia AD107 3,140,465 158,505 19.81 1 hrs 13 mins
17 GeForce RTX 3060 Ti
GA104 [GeForce RTX 3060 Ti]		 Nvidia GA104 2,626,506 158,505 16.57 1 hrs 27 mins
18 GeForce RTX 3060 Lite Hash Rate
GA106 [GeForce RTX 3060 Lite Hash Rate]		 Nvidia GA106 1,770,281 158,505 11.17 2 hrs 9 mins