RESEARCH: ALZHEIMERS
FOLDING PROJECT #15092 PROFILE

This project studies GLYT1, a protein that moves glycine in the brain. Problems with GLYT1 can cause diseases like schizophrenia and epilepsy. By simulating how GLYT1 works, scientists hope to learn how to treat these conditions.

This project simulates GLYT1, the major human glycine transporter, is responsible for terminating neurotransmission in neuronal signalling.

Deleterius mutants of GLYT1 are associated with a number of neurological diseases, including schizophrenia and hyperekplexia, and drugs targeting GLYT1 have been proposed for treatment of Alzheimers.

These simulations will provide a mechinistic study of the kinetics and thermodynamics of the intermediate processes involved in the forward transport cycle.

GLYT1

Glycine Transporter 1

GLYT1 is a protein responsible for transporting glycine, an inhibitory neurotransmitter, across cell membranes in the brain. It plays a crucial role in regulating nerve signaling and preventing excessive neuronal activity.

Schizophrenia

A chronic mental disorder characterized by disturbances in thought processes, perceptions, emotions, and behavior.

Schizophrenia is a complex brain disorder affecting how a person thinks, feels, and behaves. Symptoms include hallucinations, delusions, disorganized thinking, and difficulty with social interaction.

Hyperekplexia

A rare neurological disorder characterized by excessive muscle stiffness and exaggerated startle reflex.

Hyperekplexia causes people to have involuntary muscle spasms, especially in response to sudden movements or noise. It is often diagnosed in infancy or childhood and can be caused by genetic mutations.

Alzheimers

A progressive neurodegenerative disease that causes cognitive decline, memory loss, and behavioral changes.

Alzheimer's disease is the most common cause of dementia, affecting millions worldwide. It gradually destroys brain cells, leading to memory impairment, confusion, and difficulty with daily tasks.