RESEARCH: MYOSINS
FOLDING PROJECT #14485 PROFILE

This project looks at how myosin proteins work in the human body. Myosins are super important because they power our muscles and even help move things around inside our cells. Researchers want to understand how drugs could fix problems with myosin that cause heart diseases like cardiomyopathy.

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

myosins

Proteins that generate force in cells.

Myosins are a family of motor proteins essential for various cellular functions. They convert chemical energy into mechanical work, allowing for muscle contraction, intracellular transport, and cell division. Defects in myosin function can lead to diseases like cardiomyopathies and heart failure.

proteins

Large biomolecules essential for all life processes.

Proteins are complex molecules made up of amino acids. They play a vital role in virtually every biological process, including catalyzing reactions, transporting molecules, providing structural support, and regulating cellular activities.

cardiomyopathies

Diseases of the heart muscle.

Cardiomyopathies are a group of diseases that affect the heart muscle, making it harder for the heart to pump blood effectively. This can lead to symptoms like shortness of breath, fatigue, and chest pain.

heart failure

A serious condition where the heart cannot pump blood effectively.

Heart failure occurs when the heart muscle weakens and can't pump enough blood to meet the body's needs. This can lead to fatigue, shortness of breath, swelling in the legs and ankles, and other symptoms.