RESEARCH: MYOSINS
FOLDING PROJECT #13823 PROFILE

This project studies different types of myosin proteins found in the human body. Myosins are responsible for muscle contractions and cell movement, but they have unique properties. The project focuses on differences in speed and strength, which could help us understand diseases caused by faulty myosins, like heart problems.

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although superficially similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are especially interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Myosins

Proteins responsible for muscle contraction and cellular movement.

Myosins are essential proteins found in all cells. They generate force and power various cellular processes, including muscle contraction, intracellular transport, and cell division. Defects in myosin genes can lead to numerous diseases, such as Usher syndrome and cardiomyopathies.

Usher syndrome

A genetic disorder characterized by hearing loss and vision impairment.

Usher syndrome is a rare genetic disorder that affects both the ears and eyes. People with Usher syndrome typically experience hearing loss from birth or early childhood, along with progressive vision loss later in life. The condition is caused by mutations in specific genes involved in the development and function of the inner ear and retina.

Hypertrophic cardiomyopathy

HCM

Hypertrophic cardiomyopathy (HCM) is a heart condition characterized by the thickening of the heart muscle. This thickening can make it harder for the heart to pump blood effectively, leading to symptoms such as shortness of breath, chest pain, and fatigue. HCM is often caused by genetic mutations.

Dilated cardiomyopathy

A disease where the heart chambers enlarge and become weak.

Dilated cardiomyopathy (DCM) is a heart condition where one or more of the heart's chambers enlarge and weaken. This weakens the heart's ability to pump blood effectively, leading to symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles. DCM can be caused by various factors, including genetic mutations, viral infections, and alcohol abuse.

PDB Molecule of the Month

A monthly feature highlighting a significant protein structure.

The Protein Data Bank (PDB) Molecule of the Month is a regular feature showcasing an important protein structure. It provides detailed information about the molecule's function, structure, and relevance to various biological processes.