RESEARCH: SIGNALING PROTEIN
FOLDING PROJECT #18903 PROFILE

Mutations can seriously mess up how proteins send signals in our bodies, sometimes causing diseases. The project aims to figure out exactly how tiny changes in these signaling proteins can lead to big problems.

Impact of mutations on signaling proteins Mutations in proteins are often found to have dramatic functional consequences through changes in conformational dynamics, ligand binding, and association with signaling partners.

These changes sometimes lead to pathological outcomes.

Additionally, proteins involved in cell signaling are the target of over half of approved drugs.

This project aims to understand how a small number of mutations in signaling proteins can cause a dramatic change in how they modulate cell signaling pathways.

Mutation

A permanent alteration in the DNA sequence that makes up a gene.

Mutations are changes in the DNA code. They can be caused by errors during DNA replication or exposure to things like radiation. Mutations can have a wide range of effects, from being harmless to causing serious diseases. Many genetic disorders are caused by mutations.

Signaling Proteins

Proteins that transmit signals within and between cells.

Signaling proteins are essential for communication between cells. They relay messages about things like growth, development, and response to stimuli. When signaling proteins malfunction, it can lead to a variety of diseases.

Conformational Dynamics

The ways in which a protein's shape changes over time.

Conformational dynamics refer to the movement and flexibility of proteins. Proteins are constantly changing shape as they carry out their functions. These changes are important for how proteins interact with other molecules.

Ligand Binding

The process of a molecule (ligand) attaching to a protein.

Ligand binding is how proteins interact with other molecules. When a ligand binds to a protein, it can change the protein's shape or activity. This is important for many biological processes.

Signaling Pathways

Series of molecular interactions that transmit signals within a cell or between cells.

Signaling pathways are complex networks of molecules that relay information within and between cells. They control many important processes, such as growth, development, and immune response.

Drugs

Substances used to treat or prevent diseases.

Drugs are chemical compounds designed to interact with specific targets in the body to produce a therapeutic effect. They can be used to treat a wide range of conditions, from infections to chronic diseases.