RESEARCH: MYOSINS
FOLDING PROJECT #18305 PROFILE

This project looks at different types of myosin proteins found in the human body. Myosins are responsible for movement, like muscle contractions and moving things inside cells. The project studies how fast and powerful each type is to understand diseases caused by faulty myosins, such as heart problems and Usher syndrome.

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

Although superficially similar, myosins actually differ substantially in their properties and distribution in the body.

This project is studying those differences, especially the differences in speed and power.

We are interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies.

Myosin was featured as the PDB Molecule of the Month in June 2001.

Myosins

Proteins responsible for force generation in the body.

Myosins are proteins essential for various bodily functions like muscle contraction and cellular movement. This project focuses on understanding differences between various myosin types, which could shed light on diseases caused by myosin defects.

Usher syndrome

A rare genetic disorder causing hearing loss and vision problems.

Usher syndrome is a hereditary condition leading to both hearing impairment and vision deterioration. It often affects individuals from a young age and can significantly impact daily life.

Hypertrophic cardiomyopathy

HCM

Hypertrophic cardiomyopathy (HCM) is a heart condition where the heart muscle becomes abnormally thick, making it harder for the heart to pump blood effectively. It can lead to various complications, including chest pain, shortness of breath, and sudden cardiac arrest.

Dilated cardiomyopathy

A heart condition where the heart chambers enlarge and weaken.

Dilated cardiomyopathy (DCM) involves an enlargement and weakening of the heart's chambers, hindering its ability to pump blood effectively. This can result in fatigue, shortness of breath, fluid retention, and increased risk of heart failure.

PDB

Protein Data Bank

The Protein Data Bank (PDB) is a global repository of 3D structural data for proteins and nucleic acids. Researchers worldwide utilize this resource to understand protein function, design drugs, and advance biological research.