RESEARCH: CANCER
FOLDING PROJECT #17803 PROFILE

This project looks at BCL-XL, a protein linked to lymphoma, as a drug target. Researchers are trying to predict the 3D shapes of this protein using computer models. One method they're testing is called adaptive sampling, which helps the model learn faster. Another method, without adaptive sampling, acts as a comparison point.

BCL-XL apoptotic protein --- a drug target in lymphoma. Together with projects 17800-02 this is also testing new methodology --- adaptive sampling. This project attempts the hardest version of the problem --- prediction of all 35 crystal structures from just one of them (apo), with no adaptive sampling (in a 'vanilla' way, for comparison to the adaptive sampling algorithms).

BCL-XL

B-cell lymphoma-extra large protein

BCL-XL is a protein that plays a role in preventing programmed cell death (apoptosis) in cells. It is often overexpressed in cancer cells, making it a target for drug development in various cancers, including lymphoma.

apoptotic protein

A protein involved in the process of programmed cell death (apoptosis).

Apoptotic proteins are crucial for regulating cell death. They participate in a complex cascade of events that lead to the dismantling and removal of damaged or unwanted cells. Dysregulation of apoptosis can contribute to various diseases, including cancer.

lymphoma

A type of cancer that affects the lymphatic system.

Lymphoma is a group of cancers that develop in the lymphatic system, which plays a vital role in immune function. It can affect lymph nodes, spleen, bone marrow, and other tissues. Treatment options depend on the specific type and stage of lymphoma.

drug target

A molecule or biological pathway that is a potential therapeutic target for drug development.

Drug targets are essential components in the process of developing new medications. They represent specific molecules or processes involved in disease pathways that can be modulated by drugs to achieve therapeutic effects.

crystal structures

The three-dimensional arrangement of atoms in a molecule.

Crystal structures provide insights into the shape and organization of molecules, including proteins and small drug compounds. This information is crucial for understanding how molecules interact with each other and for designing new drugs.