RESEARCH: CANCER
FOLDING PROJECT #17801 PROFILE

This project looks at BCL-XL, a protein that stops cells from dying, as a potential drug target for lymphoma. They're testing new ways to analyze data called 'adaptive sampling', which hasn't been used in this kind of research before.

BCL-XL apoptotic protein --- a drug target in lymphoma.

More info coming soon.

Together with project 17800 this is also testing new methodology --- adaptive sampling.

This is the adaptive (first time on F@h) sampling version of the system.

BCL-XL

B-cell lymphoma-extra large protein

BCL-XL is a protein that plays a role in regulating cell death (apoptosis). In certain types of cancer, like lymphoma, BCL-XL levels are often high, which can prevent cells from dying properly and contribute to the growth of tumors. Therefore, BCL-XL has become a drug target for cancer therapy.

apoptotic protein

A protein involved in the process of programmed cell death (apoptosis).

Apoptotic proteins are essential for normal cellular function. They control the process of apoptosis, which is a natural and controlled way for cells to die. This process is important for removing damaged or unwanted cells, as well as for regulating tissue development and homeostasis. In cancer, defects in apoptotic pathways can lead to uncontrolled cell growth and tumor formation.

drug target

A specific molecule (protein, enzyme, receptor) that is involved in a disease pathway and is targeted by drugs to treat the disease.

Drug targets are essential for developing new therapies. By identifying and understanding the molecules that contribute to disease progression, researchers can design drugs that specifically inhibit or modulate their activity. This targeted approach can lead to more effective treatments with fewer side effects.

lymphoma

A type of cancer that affects the lymphatic system, which is part of the immune system.

Lymphoma involves the abnormal growth of lymphocytes, a type of white blood cell. There are different subtypes of lymphoma, classified based on the type of lymphocyte involved and the aggressiveness of the disease. Treatment options for lymphoma include chemotherapy, radiation therapy, immunotherapy, and stem cell transplantation.