RESEARCH: CANCER
FOLDING PROJECT #17750 PROFILE

This project looks at how special proteins in our bodies move molecules across cell walls using ion power! These proteins are important for things like fighting cancer and diabetes, and studying them helps us understand how they work across different types of cells.

Projects 17745-17750 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

Secondary active transporters

Proteins that use ions to transport molecules across cell membranes.

Secondary active transporters are essential proteins found in all living organisms. They work by using an existing ion gradient to power the movement of other molecules across cell membranes. This process is vital for many cellular functions, including nutrient uptake, waste removal, and signal transduction. Many of these transporters are also drug targets for treating various diseases.

Ion Gradient

A difference in ion concentration across a cell membrane.

An ion gradient refers to an unequal distribution of ions (charged atoms) on either side of a cell membrane. This difference in concentration creates an electrical potential that can be harnessed by cells to perform essential functions, such as transporting molecules across the membrane.

Drug Targets

Molecules or pathways that are potential sites for drug action.

Drug targets are specific molecules or cellular processes that are involved in the development or progression of diseases. By targeting these molecules with drugs, researchers aim to disrupt the disease pathway and alleviate symptoms.

Simulations

Computer models used to represent and study biological systems.

Simulations are powerful tools used in computational biology to model complex biological processes. By running simulations on computers, researchers can explore how different variables influence system behavior and gain insights into biological mechanisms.

Proteins

Large, complex molecules essential for virtually all biological functions.

Proteins are the workhorses of the cell, carrying out a vast array of functions essential for life. They are involved in everything from catalyzing biochemical reactions to transporting molecules across cell membranes.