RESEARCH: CANCER
FOLDING PROJECT #17505 PROFILE

Four projects use computer simulations to study how proteins AURKA and N-MYC interact. Some projects include a special molecule called a ligand. Projects 17505, 17506, and 17507 explore interactions at normal temperatures, while Project 17508 uses higher temperatures.

Note: This TLDR is a simplication and may not be 100% accurate.

Project 17505 is room-temperature vanilla simulation of an apo kinase AURKA : N-MYC complex to explore protein-protein interactions.
Project 17506 is room-temperature vanilla simulation of the kinase AURKA : N-MYC complex with ligand 1 bound to explore protein-protein interactions.
Project 17507 is room-temperature vanilla simulation of the kinase AURKA : N-MYC complex with ligand 2 bound to explore protein-protein interactions.
Project 17508 is high-temperature vanilla simulation of an apo kinase AURKA : N-MYC complex to explore protein-protein interactions.

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AURKA

Auras kinase

Aurora Kinase A (AURKA) is an enzyme that plays a crucial role in cell division. It helps organize microtubules, which are protein structures that separate chromosomes during cell division.

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N-MYC

Neuroblastoma MYC amplification

N-MYC is a gene that plays a role in cell growth and division. It is often amplified (copied multiple times) in neuroblastoma, a type of childhood cancer.

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Protein-protein interactions

The binding of two or more proteins together.

Protein-protein interactions are essential for many cellular processes. They allow proteins to work together in complex networks to carry out tasks such as signaling, metabolism, and DNA replication.

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Kinase

An enzyme that transfers a phosphate group from ATP to a substrate molecule.

Kinases are important regulators of cellular processes. They add phosphate groups to proteins, which can change their activity and function.

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Ligand

A molecule that binds to a receptor or protein.

Ligands are often used in drug development. They can bind to specific receptors and trigger biological responses.