RESEARCH: COVID-19
FOLDING PROJECT #17311 PROFILE

This project looks at how a mutation in the SARS-CoV-2 virus affects its ability to bind to human cells and be neutralized by antibodies. By simulating these changes, scientists hope to better understand the virus and develop new treatments.

Note: This TLDR is a simplication and may not be 100% accurate.

This project involves the SARS-CoV-2 receptor binding domain (RBD) and its target receptor in humans, ACE2.

We are simulating mutants of these proteins in complex with each other (with glycosylation).

The results from this study will help guide our understanding of how a natural mutation in the RBD (that arose in Scotland) impacts RBD:ACE2 binding as well as as antibody neutralization.

Ultimately, the knowledge gained here will help infom drug design efforts.

---

SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 is the virus responsible for causing COVID-19. It's a type of coronavirus that spreads through respiratory droplets and can lead to severe respiratory illness.

---

RBD

Receptor binding domain

The receptor binding domain (RBD) is a part of the spike protein on SARS-CoV-2. It's responsible for attaching to the ACE2 receptor on human cells, allowing the virus to enter and infect.

---

ACE2

Angiotensin-converting enzyme 2

ACE2 is a protein found on the surface of many human cells, including those in the lungs and heart. SARS-CoV-2 uses ACE2 as a receptor to enter cells.

---

Glycosylation

The process of adding sugar molecules to proteins

Glycosylation is a common modification of proteins where sugar molecules are attached. It can affect protein structure, function, and stability.

---

Mutants

Genetically altered organisms or cells

Mutants are organisms or cells that have undergone genetic changes. These changes can be natural or induced in the lab.

---

Antibody Neutralization

The process of antibodies blocking the action of a virus

Antibody neutralization is a key mechanism of the immune system's response to viral infection. Antibodies can bind to viruses and prevent them from attaching to and infecting cells.

---

Drug Design

The process of creating new drugs

Drug design involves identifying and optimizing molecules that can interact with specific biological targets to treat diseases.