RESEARCH: RIPK1-VHL-INTERACTION
FOLDING PROJECT #16771 PROFILE

This project looks at how two proteins, RIPK1 and VHL, interact. By understanding their different forms, scientists hope to design new drugs called PROTACs that can target and control these proteins.

This project is going to investigate the protein-protein interaction between ripk1 and E3 ligase vhl.

Examing the appropriate metastable states will facilitate the design of PROTAC.

RIPK1

Receptor-interacting protein kinase 1

RIPK1 is a protein that plays a crucial role in regulating cell death and inflammation. It's involved in various signaling pathways triggered by cellular stress or damage.

E3 ligase

Enzymes that tag proteins for degradation by the proteasome

E3 ligases are a type of enzyme that act as matchmakers in the cellular protein recycling system. They attach small protein tags called ubiquitins to target proteins, marking them for destruction by the proteasome.

VHL

Von Hippel-Lindau

VHL is a tumor suppressor protein that regulates cell growth and prevents the formation of tumors. Mutations in VHL can lead to various cancers.

PROTAC

Proteolysis-Targeting Chimera

PROTACs are a novel class of drugs that leverage the cell's natural protein degradation machinery to target and eliminate specific disease-causing proteins.