RESEARCH: OGT-SMG9-COMPLEX-SIMULATION
FOLDING PROJECT #16722 PROFILE

This project explores how a molecule called OGT works when combined with a special peptide called SMG9. Researchers want to create a computer model of this combination to better understand how they interact.

This project focuses on the allosteric effect of O-GlcNAc transferase (OGT) and SMG9 peptide.

We aim to simulate the complex of OGT and SMG9.

allosteric

Describes a change in protein function due to binding at a site other than the active site.

Allosteric refers to a type of regulation where a molecule binds to a protein at a location different from its active site. This binding can either enhance or inhibit the protein's activity, influencing its overall function.

O-GlcNAc transferase

OGT

O-GlcNAc transferase (OGT) is an enzyme that adds a sugar molecule called O-GlcNAc to proteins. This process, known as O-GlcNAcylation, plays a role in regulating various cellular functions, including gene expression and protein stability.

SMG9

Not readily available

SMG9 is a protein involved in the surveillance and degradation of aberrant messenger RNA (mRNA) molecules. This process ensures the quality control of gene expression by eliminating defective transcripts.

peptide

A short chain of amino acids linked together.

A peptide is a small protein made up of a sequence of amino acids. Peptides can have various biological functions, such as acting as hormones, enzymes, or signaling molecules.

complex

A group of two or more molecules interacting with each other.

A complex is formed when two or more molecules come together and interact. These interactions can be temporary or permanent and often involve specific binding sites on the molecules.